Traduction de «Long-term follow-up cohorts » (Anglais → Français) :

Question No. 53 Ms. Kirsty Duncan: With respect to the chronic cerebrospinal venous insufficiency (CCSVI) clinical trial being undertaken by Dr. Traboulse: (a) what milestones are reportable to the government, (i) on what date(s) is reporting expected to occur, (ii) how will this information be communicated to patients, the medical community, and the general public; (b) on what date did each of the trial sites pass ethical review; (c) on what date did recruitment of patients begin for each of the trial sites; (d) how many patients with multiple sclerosis (MS) are being recruited for each site, and how is consistency in diagnosis and treatment being ensured across sites; (e) who is performing the diagnoses for CCSVI for each site, (i) ho ...[+++]w is the diagnosis being performed, including, but not limited to, ultrasound and venogram, (ii) how many diagnoses has each person undertaking the diagnosis at each site performed prior to the study, and by whom was each person trained; (f) who is performing the procedures for each site, (i) how is the procedure being performed, including, but not limited to, anesthetic, balloon size, (ii) how many procedures has each person undertaking the procedure at each site performed prior to the study, and by whom was each person trained; (g) what are the selection criteria for the trial, including, but not limited to, type of MS, Expanded Disability Status Scale (EDSS) score, venous abnormality/malformed valve/stenosis, mobility, (i) how do these criteria compare with the international literature, (ii) with how many international studies to date will the selection criteria be analytically comparable; (h) if both progressive and relapsing-remitting forms of MS are to be examined in the trial, how will statistical significance be ensured given that 50 of 100 patients will undergo a “sham” procedure, 25 patients will have a progressive form of the disease, and 25 will have a relapsing-remitting form of the disease, and will people with bo ...

Approaches will include the long term study of cohorts and their linkage with data derived from "omics" research, systems bio-medicine including relevant applications of systems biology and other methods.

We have five recommendations to maximize its deployment in Quebec (1205) Mr. Pierre Gingras: These are the five recommendations: first, that HRSDC acknowledge the specific nature of the intervention by Carrefour jeunesse-emploi through the Skills Link initiative, particularly with respect to evaluation and case management; that the department grant funding to the CJEs for case management or youth assessment according to local needs and realities; that HRSDC promote the active participation of its officers on local development committees and project follow-up; that the department rapidly examine the possibility of granting funding for ...[+++]case management and evaluation of participants on a three-year basis, in order to ensure continuity of service and long term follow-up of young people; finally, in the mean time, that HRSDC grant the renewal of agreements that have already been signed with Carrefour jeunesse-emploi for case management and evaluation of participants.

Therefore, an additional requirement for applying for a marketing authorisation that includes the results of studies conducted in compliance with an agreed paediatric investigation plan should be an obligation for the applicant to indicate how he proposes to ensure the long-term follow-up of possible adverse reactions to the use of the medicinal product and efficacy in the paediatric population.

It is imperative that there be long term follow-up, which would require an offender to report in for a period to be determined in accordance with the sentence handed down.

Some long term follow-up studies reveal death rates of up to 18% in affected individuals.